In early 1796 the Inniskillings once again accompanied an expeditionary force to the West Indies.

Having taken a prominent part in the recapture of St Lucia, the Regiment, apart from small detachments at Barbados and Dominica, remained quartered at Grenada for nearly two years. During this period the Regiment suffered terribly from the ravages of the climate and disease. By the end of 1796 more than 400 officers and men had died, while many of the remainder were sick.

Despite the arrival of drafts on 24 December 1797, the effective strength all told was only 283.